The presenter, who regularly fronts the BBC Two spin-off show, was replaced by former Strictly contestant Gethin Jones.
Reports emerged saying that Zoe has been suffering from a “nasty stomach bug” and tonight, Gethin revealed that she was still recovering from the illness.
A spokesperson confirmed the blonde beauty’s absence, commenting: “”She is at home resting and hoping to feel better for Blackpool weekend.
“She is thankful to Gethin for stepping in last minute.”
As Getting stepped in for a second night, viewers at home rushed to Twitter to send their well wishes to Zoe and begged for her to recover soon.
One fan of the BBC series, tweeted: “#@ZoeTheBall @bbcstrictly #ItTakesTwo Aw Zoe. I am missing you on TV right now. But I hope you get well soon. It’s not the same without you hosting #ittakestwo. Hope you’ll be back!”
As another added: “#ItTakesTwo where is Zoe ball I can’t wait this with this idiot.”
“I miss zoe on #ItTakesTwo -gethin jones is the most boring presenter on tv -yawn” a third continued.
While someone else shared: “Miss you @ZoeTheBall, get well soon! Love ya. #ItTakesTwo.”
However, there were some viewers who insisted Gethin should be given a more permanent role on the show in future, with one commenting: “Missing @ZoeTheBall on #ItTakesTwo but Gethin is a fab stand in. He and Ian Waite dancing together.”
As another tweeted: “#ittakestwo Perhaps @ZoeTheBall & @GethincJones could take it in turns, both different persenting styles & change would be nice.”